- "Can't get enough of that wonderful Duff"
- ―Duff Brewery's motto
The Duff Brewery in Springfield is the place where Duff Beer is made. The tour of the brewery is very popular. Most visitors to the Duff Brewery leave with a greater-than-16 blood-alcohol level, due to the copious amounts of free beer samples.
The Duff Brewery was located on an island in the middle of a river, and a bridge was originally supposed to be opened after construction, but due to Homer's stupidity he blew the bridge up when throwing Dynamite used to demolish the old Springfield Mall into the river the day before it was supposed to open, causing Trucks containing Duff Beer to fall into the river.
||The contents of this article or section are considered to be non-canon and therefore may not have actually happened or existed.
 The Simpsons Game
In "The Simpsons Game", level "Around the World in 80 Bites", the factory's interior is decorated with different countries ambients for an eating contest.