- For his superhero alias, see Dewey Largo (When Bongos Collide!).
Dewey Largo is the music teacher whom Lisa credited with proving that any piece of music could have the soul sucked out of it. He is very counter-creative and is a poor conductor.
As a child, Dewey Largo was accepted to the Juilliard School of Music, but never got the letter as it was frozen atop Mt. Springfield. His assumed rejection from this school could explain his eventual lack of passion for music.
Largo attended to the arts camp Expressions when he was a child, and told Lisa "it's just a place where they fill people with fake dreams."
Mr. Largo is the music teacher at Springfield Elementary School. He is one of the more uptight and mean teachers at the school. Largo teaches Lisa's band class where he often stifles her creativity. He only teaches simple, boring and unoriginal songs to the band causing Lisa to often cause outbursts in class by improvising on her saxophone. Once, Mr. Largo had to take over for Groundskeeper Willie for a short time while Willie was working at The Gilded Truffle. He turned out to an even worse groundskeeper than a music teacher. He wanted to have a sex change operation to look like Julie Newmar, but ended up becoming shorter instead because Dr. Nick mixed up his surgery file with Moe's.
Dewey Largo is gay, but was closeted for a long time. He was once in a large car crash and was rescued from the same car as Waylon Smithers, Jr. and was quick to state that they were just carpooling. Later he was in a gay pride parade and quickly changed the subject when he was asked about it. He was later seen trying to enter The League of Extra-Horny Gentlemen and being denied entrance by the doorman. Shortly after that, he "outed" himself when he ran away with his boyfriend, also named Dewey.
 Behind the Laughter
- His last name is also an Italian word for a slow, broad musical tempo, a possible reference to the fact that he can make any piece of music uninteresting.
- Largo is voiced by Harry Shearer and was once voted the worst character created.
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